Human Papillomavirus (HPV) Transcripts in Malignant Inverted Papilloma are from Integrated HPV DNA

Abstract

HPV transcripts were present in SCC positive for HPV, and the relative level of E7 to E5 transcripts indicates integration of the viral genome. These findings are suggestive of HPV having an active role in the lesion. More extensive studies are needed to determine the exact role of HPV in IP and progression to SCC.