Concepedia

Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity

John Nemunaitis, Casey Cunningham, A Buchanan, A. Blackburn, Gerald M. Edelman, Phillip B. Maples, George J. Netto, Alina Y Tong, Britta Randlev, S.C. Olson,

Gene Therapy · 2001 · 282 citations · 81 references

DOI

Concepts

References

81

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

Thomas J. Wickham, Patricia Mathias, David A. Cheresh et al. · Cell · 1993 · 2.2K citations

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Phosphatidylinositol-3-OH kinase direct target of Ras

Pablo Rodriguez‐Viciana, Patricia H. Warne, Ritu Dhand et al. · Nature · 1994 · 1.9K citations

, , +12

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

James R. Bischoff, David H. Kirn, Angelica Williams et al. · Science · 1996 · 1.8K citations

, , +14

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

Fadlo R. Khuri, John Nemunaitis, Ian Ganly et al. · Nature Medicine · 2000 · 1.1K citations

, , +8

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

Robert L. Martuza, Amy Malick, James M. Markert et al. · Science · 1991 · 1K citations

, , +14