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A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature · 2000 · 6.4K citations

Toll-like Receptors, Virulence Factor, Pathogenesis +7

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

Natural Sciences, Virulence Factor, Cpg Motifs +4

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

Elizabeth A. Leadbetter, Ian R. Rifkin, Andreas M. Hohlbaum et al. · Nature · 2002 · 1.9K citations

Toll-like Receptors, Molecular Immunology, Chromatin +13

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

Ricardo E. Dolmetsch, Richard S. Lewis, Christopher C. Goodnow et al. · Nature · 1997 · 1.7K citations

Transcription Factors, Signal Transduction, Ca2+ Response Amplitude +13

A Theory of Self-Nonself Discrimination

Peter A. Bretscher, Melvin Cohn · Science · 1970 · 1.7K citations

Discrimination, Immunology, Immunologic Mechanism +23