Concepedia

Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor

Sonia Martı́nez, Ana Isabel Hernández, Carmen Varela, Sonsoles Rodríguez-Arístegui, Milagros Lorenzo, Antonio Rodrı́guez, Virginia Rivero‐Buceta, Carl Gustav Saluste, F.J. Ramos-Lima, Elena Cendón,

Bioorganic & Medicinal Chemistry Letters · 2012 · 24 citations · 16 references

DOIFull text

Open access

Concepts

References

16

High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers

Yardena Samuels, Zhenghe Wang, Alberto Bardelli et al. · Science · 2004 · 3.4K citations

, , +11

PIK3CA is implicated as an oncogene in ovarian cancer

Laleh Shayesteh, Yiling Lu, Wen-Lin Kuo et al. · Nature Genetics · 1999 · 1.2K citations

, , +12

Mutation of the <b> <i>PIK3CA</i> </b> Gene in Ovarian and Breast Cancer

Ian Campbell, Sarah E. Russell, David Y.H. Choong et al. · Cancer Research · 2004 · 914 citations · Full text

, , +17

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

Sohye Kang, Andreas G. Bader, Peter K. Vogt · Proceedings of the National Academy of Sciences · 2005 · 824 citations · Full text

, , +17

RAS Interaction with PI3K: More Than Just Another Effector Pathway

Esther Castellano, Julian Downward · Genes & Cancer · 2011 · 755 citations · Full text

, , +17