Concepedia

Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

Masahiro Shuda, Nobuo Kondoh, Nobuo Imazeki, Kenji Tanaka, Tetsuya Okada, Kazutoshi Mori, Akiyuki Hada, Masaaki Arai, Toru Wakatsuki, Osamu Matsubara,

Journal of Hepatology · 2003 · 515 citations · 34 references

DOI

Concepts

References

34

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

Hiderou Yoshida, Toshie Matsui, Akira Yamamoto et al. · Cell · 2001 · 4.1K citations · Full text

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Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

Kyosuke Haze, Hiderou Yoshida, Hideki Yanagi et al. · Molecular Biology of the Cell · 1999 · 2K citations

, , +15

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

Hélène Zinszner, Masahiko Kuroda, X. Wang et al. · Genes & Development · 1998 · 2K citations · Full text

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ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

Jin Ye, Robert B. Rawson, Ryutaro Komuro et al. · Molecular Cell · 2000 · 1.8K citations · Full text

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An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

Sean Munro, Hugh R.B. Pelham · Cell · 1986 · 1.5K citations

, , +10