FEBS Letters · 1985 · 53 citations · 22 references
Life SciencesCell BiologyMolecular BiologyChromatin BiologyChromatin StructureStructural BiologyChromatinChromatin ArchitectureChromatin BiophysicsHistone ProteinsNucleosome OrganizationNucleosome StructureChromatin Fiber GeometryChromatin Fiber ModelingChromatin Fiber OrganizationChromatin Fiber StructureChromatin FibersLinear DichroismStructural Models Of Chromatin FiberTriple Helix Structure
A model of chromatin fiber structure is presented in which a repeating unit of a trinucleosome forms a 3-dimensional zigzag. Twisting and compression of the zigzag result in a triple helix structure. The model is built mainly on the flow linear dichroism data showing that nucleosomal disc faces are tilted relative to the fiber axis, the orientation of nucleosomes does not change upon folding and unfolding of chromatin, and the orientation of nucleosomes is maintained by the globular domain of histone H1.
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The structure of histone H1 and its location in chromatin
James M. Allan, Peter Hartman, Colyn Crane‐Robinson et al. · Nature · 1980 · 707 citations