Planta Medica · 1983 · 105 citations · 0 references
Life SciencesBiochemistryPharmacologyBiochemical PharmacologyFood ChemistryHepatotoxicologyHepatic PathophysiologyHepatic ToxicityHepatotoxicity MechanismsLipid PeroxidationMechanisms Of Toxic InjuryOxidative Stress In HepatotoxicityAntioxidant Protection Against HepatotoxicityLipid Peroxidation In HepatotoxicityLipid Peroxidation MarkersLiver Injury ModelsOxidative Stress In Liver InjuryPolygonum Multiflorum HepatotoxicityProtective AntioxidantsRat Liver Microsomes
The effects of Polygonum cuspidatum SIEB. et Zucc. ("Kojo-kon" or "Itadori-kon" in Japanese) of Polygonum multiflorum ("Kashuwu" or "Tsurudo-kudami-kon" in Japanese) roots and their stilbene components (piceid and 2,3,5,4′-tetrahydroxy stilbene-2-O-D-glucoside) on liver injury caused in rats by feeding peroxidized oil were investigated. Piceid and 2,3,5,4′-tetrahydroxy stilbene-2-O-D-glucoside were found to partly inhibit the deposition of lipid peroxides in the liver of those rats. The stilbene glucosides reduced the elevation of GOT and GPT levels in the serum of the rats. Furthermore, resveratrol, piceid and 2,3,5,4′-tetrahydroxy stilbene-2-O-D-glucoside were found to inhibit lipid peroxidation induced by ADP and NADPH in rat liver microsomes.