Science · 1977 · 515 citations · 16 references
MedicinePharmacologyMembrane BiochemistryMembrane BiophysicsMolecular PharmacologyAlcohol PharmacologyAlcohol ToleranceDrug ToleranceMembrane FluidityMembrane PermeabilityMembrane StabilizationEthanol ToleranceSpin-dependent Transport In Membranes
Ethanol in vitro increased the fluidity of spin-labeled membranes from normal mice. Membranes from mice that had been subjected to long-term ethanol treatment were relatively resistant to this fluidizing effect. The data suggest that the membranes themselves had adapted to the drug, a novel form of drug tolerance.
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