Concepedia

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Lisa Hasvold, Le Wang, Magdalena Przytulinska, Zhan Xiao, Zehan Chen, Wen‐Zhen Gu, Philip J. Merta, John Xue, Peter Kovar, Haiying Zhang,

Bioorganic & Medicinal Chemistry Letters · 2008 · 15 citations · 5 references

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5

G2 checkpoint abrogators as anticancer drugs

Takumi Kawabe · Molecular Cancer Therapeutics · 2004 · 383 citations · Full text

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Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents

Zhan Xiao, Zehan Chen, Angelo Gunasekera et al. · Journal of Biological Chemistry · 2003 · 382 citations · Full text

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162 Differential sensitivity of P53+ and P53- cells to caffeine-induced radiosensitization and override of G2 delay

S.N. Powell, Jeffrey S. DeFrank, Paul Connell et al. · International Journal of Radiation Oncology*Biology*Physics · 1995 · 269 citations

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Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[<i>b</i>,<i>e</i>][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

Le Wang, Gerard M. Sullivan, Laura A. Hexamer et al. · Journal of Medicinal Chemistry · 2007 · 43 citations · Full text

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Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors

Yunsong Tong, Akiyo Claiborne, Kent D. Stewart et al. · Bioorganic & Medicinal Chemistry · 2007 · 40 citations · Full text

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