Concepedia

Antitumour drugs impede DNA uncoiling by topoisomerase I

Daniel A. Koster, Komaraiah Palle, Elisa S. M. Bot, Mary‐Ann Bjornsti, Nynke H. Dekker

Nature · 2007 · 288 citations · 20 references

DOI

Concepts

References

20

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

, , +15

Supercoiling of the DNA template during transcription.

Leroy F. Liu, J C Wang · Proceedings of the National Academy of Sciences · 1987 · 2K citations · Full text

, , +17

The Elasticity of a Single Supercoiled DNA Molecule

Terence R. Strick, Jean‐François Allemand, David Bensimon et al. · Science · 1996 · 1.3K citations

, , +15

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

Y H Hsiang, M G Lihou, Leroy F. Liu · PubMed · 1989 · 1K citations

, , +17

Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

Matthew R. Redinbo, Lance Stewart, Peter Kühn et al. · Science · 1998 · 878 citations

, , +13