Publication | Closed Access
Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents
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Citations
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References
2002
Year
Medicinal ChemistryNovel C2-arylMedicineCell LinesNovel C2-aryl PyrrolobenzodiazepinesSelective CytotoxicityPharmacological AgentPharmacotherapyTumor TargetingAnti-cancer AgentHeterocycle ChemistryDrug DevelopmentPharmacologyRadiation OncologyPharmaceutical ChemistryTumor BiologyDrug Discovery
Three novel C2-aryl substituted pyrrolobenzodiazepines (PBDs) have been synthesised and evaluated in a number of cell lines revealing selective cytotoxicity at the sub-nanomolar level towards melanoma and ovarian cancer cell lines.
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