RNA Interference Suggests a Primary Role for Monoacylglycerol Lipase in the Degradation of the Endocannabinoid 2-Arachidonoylglycerol

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, Siqun Xu, Mary K. Montgomery et al. · Nature · 1998 · 15.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +8

Brain monoglyceride lipase participating in endocannabinoid inactivation

T. P. Dinh, D. L. Carpenter, F.M. Leslie et al. · Proceedings of the National Academy of Sciences · 2002 · 1.4K citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

Benjamin F. Cravatt, Kristin Demarest, Matthew P. Patricelli et al. · Proceedings of the National Academy of Sciences · 2001 · 1.3K citations · Full text

Medicine, Neuroscience, Pharmacology +13

Modulation of anxiety through blockade of anandamide hydrolysis

Satish Kathuria, Silvana Gaetani, Darren Fegley et al. · Nature Medicine · 2002 · 1.3K citations · Full text

Medicine, Neuroscience, Pharmacology +12

Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition

Massimiliano Beltramo, Nephi Stella, Antonio Calignano et al. · Science · 1997 · 807 citations · Full text

Life Sciences, Neuroscience, Pharmacology +15