Concepedia

NSAID-induced gastrointestinal damage: the biochemical consequences of the 'ion trapping' hypothesis

G Sigthorsson, Jeremy Tibble, Taher Mahmud, Ingvar Bjarnason

Inflammopharmacology · 2000 · 17 citations · 15 references

DOI

Concepts

References

15

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

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Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

Robert Langenbach, Scott G. Morham, Howard F. Tiano et al. · Cell · 1995 · 1.1K citations · Full text

, , +16

Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat

Brendan J.R. Whittle · Gastroenterology · 1981 · 441 citations

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Mitochondrial damage: a possible mechanism of the “topical” phase of NSAID induced injury to the rat intestine

Siva G. Somasundaram, S Rafi, Jeremy Hayllar et al. · Gut · 1997 · 317 citations · Full text

, , +17

Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury

Lenard M. Lichtenberger, Zu-Mo Wang, Jimmy J. Romero et al. · Nature Medicine · 1995 · 305 citations

, , +15