The role of Bax and Bcl-2 in gemcitabine-mediated cytotoxicity in uveal melanoma cells

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Zoltán N. Oltval, Curt Milliman, Stanley J. Korsmeyer · Cell · 1993 · 6K citations

Life Sciences, Cell Biology, Molecular Biology +12

Gemcitabine: metabolism, mechanisms of action, and self-potentiation.

William Plunkett, Peng Huang, Yi-Zheng Xu et al. · PubMed · 1995 · 756 citations

Life Sciences, Pharmacokinetics, Pharmacology +6

2′,2′-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines

Veronique W.T. Ruiz van Haperen, Gijsbert Veerman, Jan B. Vermorken et al. · Biochemical Pharmacology · 1993 · 254 citations

Medicine, Molecular Biology, Oncology +10

T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage‐induced cell death in the absence of p53.

Hugh J.M. Brady, G. S. Salomons, René C. Bobeldijk et al. · The EMBO Journal · 1996 · 127 citations · Full text

Life Sciences, Cell Biology, Immunology +13

Expression of a non‐functional p53 affects the sensitivity of cancer cells to gemcitabine

Carlos M. Galmarini, Marilyn L. Clarke, Nicole Falette et al. · International Journal of Cancer · 2001 · 98 citations · Full text

Medicine, Oncology, Pharmacology +16