Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

Yuesheng Zhang, Paul Talalay, C G Cho et al. · Proceedings of the National Academy of Sciences · 1992 · 1.7K citations

Life Sciences, Biochemistry, Toxicology +16

A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia<i>In Vivo</i>

Andy Y. Shih, Ping Li, Timothy H. Murphy · Journal of Neuroscience · 2005 · 411 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Neutrophil-independent mechanisms of caspase-1– and IL-18–mediated ischemic acute tubular necrosis in mice

Vyacheslav Y. Melnikov, Sarah Faubel, Britta Siegmund et al. · Journal of Clinical Investigation · 2002 · 344 citations · Full text

Medicine, Immunology, Pathology +17

Neutrophil-independent mechanisms of caspase-1– and IL-18–mediated ischemic acute tubular necrosis in mice

Vyacheslav Y. Melnikov, Sarah Faubel, Britta Siegmund et al. · Journal of Clinical Investigation · 2002 · 314 citations · Full text

Medicine, Immunology, Pathology +17

Reoxygenation‐specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia‐reperfusion injury

Martin O. Leonard, Niamh E. Kieran, Katherine B. Howell et al. · The FASEB Journal · 2006 · 253 citations

Life Sciences, Biochemistry, Physiology +12