Towards Elucidation of the Role of Ubiquitination in the Pathogenesis of Parkinson’s Disease with Semisynthetic Ubiquitinated α‐Synuclein

Abstract

Ubiquitinate me here: The semisynthesis and characterization of a site-specifically monoubiquitinated form of α-synuclein (see picture) enabled investigation of the effect of ubiquitination on membrane binding, oligomerization, and fibrillogenesis. The introduction of specific ubiquitin modifications into α-synuclein will shed light on the role of ubiquitination in regulating the function(s) of α-synuclein in health and disease. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.