Concepedia

Topologically Heterogeneous Beta Cell Adaptation in Response to High-Fat Diet in Mice

Johanne H. Ellenbroek, H.A.M. Töns, Natascha de Graaf, Cindy J.M. Loomans, Marten A. Engelse, Hans Vrolijk, Peter J. Voshol, Ton J. Rabelink, Françoise Carlotti, Eelco J.P. de Koning

PLoS ONE · 2013 · 45 citations · 22 references

DOIFull text

Open access

Abstract

HFD-induced insulin resistance leads to topologically heterogeneous beta cell adaptation and is most prominent in the splenic region of the pancreas. This topological heterogeneity in beta cell adaptation appears to result from extrinsic factors present in the islet microenvironment.

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