Inhibition of Vascular Smooth Muscle Cell Proliferation and Neointimal Accumulation by Adenovirus-Mediated Gene Transfer of Cytosine Deaminase - Concepedia

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Inhibition of Vascular Smooth Muscle Cell Proliferation and Neointimal Accumulation by Adenovirus-Mediated Gene Transfer of Cytosine Deaminase

60

Citations

20

References

1997

Year

Robert L. Harrell, M. A. Sharmini Rajanayagam, A. Masharn Doanes, Raul J. Guzman, Edward A. Hirschowitz, Ronald G. Crystal, Stephen E. Epstein, Toren Finkel

Abstract

Our results suggest that adenovirus-mediated gene transfer of CD along with 5-FC administration may be a useful strategy to treat the proliferative aspects of restenosis.

References

	Year	Citations
Significance of quiescent smooth muscle migration in the injured rat carotid artery. A W Clowes, Stephen M. Schwartz Circulation Research Vascular DiseaseCellular PhysiologyMuscle InjurySkeletal MuscleNeurology	1985	571
Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Craig A. Mullen, Mogens Kilstrup, R. Michael Blaese Proceedings of the National Academy of Sciences Cytosine DeaminaseMolecular BiologyBacterial GeneToxic Compound 5-FluorouracilDrug Resistance	1992	504
Cytostatic Gene Therapy for Vascular Proliferative Disorders with a Constitutively Active form of the Retinoblastoma Gene Product Mark W. Chang, Eliav Barr, Jonathan Seltzer, Science Vascular DiseaseIn Vivo Gene TherapyImmunologyPathologyVascular Smc Proliferation	1995	448
Gene Therapy for Vascular Smooth Muscle Cell Proliferation After Arterial Injury Takeshi Ohno, David J. Gordon, Hong San, Science Herpesvirus Thymidine KinaseAngiogenesisMolecular PhysiologyMedicineBalloon Injury	1994	439
<i>In Vitro</i> Evidence That Metabolic Cooperation Is Responsible for the Bystander Effect Observed with HSV <i>tk</i> Retroviral Gene Therapy Wan Li Bi, Linda M. Parysek, Ronald E. Warnick, Human Gene Therapy	1993	420
Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Brian E. Huber, Elizabeth A. Austin, C A Richards, Proceedings of the National Academy of Sciences Cytosine DeaminaseImmunologyCancer BiologyGliomaTumor Mass	1994	420
Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. M W Chang, Emily Barr, Min Lü, Journal of Clinical Investigation Vascular DiseaseImmunologyPathologyCell CycleP21-encoding Adenovirus	1995	356
Drug sensitivity ("suicide") genes for selective cancer chemotherapy. Moolten Fl PubMed Selective Cancer ChemotherapyMedicinePharmacologyCancer TreatmentCancer Genetics	1994	275
Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro. Elshami Aa, Alene Saavedra, Hongtao Zhang, PubMed	1996	260
Targeting of an inducible toxic phenotype in animal cells. Emiliana Borrelli, Richard A. Heyman, Megan Hsi, Proceedings of the National Academy of Sciences Viral ReplicationSynthetic VirologyImmunologyMolecular BiologyCell Death	1988	249

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