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Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells

Hemad Yasaei, E Gilham, Jessica C. Pickles, Timothy P. L. Roberts, Michael R. O’Donovan, Robert F. Newbold

Oncogene · 2012 · 65 citations · 37 references

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37

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text

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MethPrimer: designing primers for methylation PCRs

Long-Cheng Li, Rajvir Dahiya · Bioinformatics · 2002 · 2.8K citations · Full text

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Signatures of mutation and selection in the cancer genome

Graham R. Bignell, Chris Greenman, Helen Davies et al. · Nature · 2010 · 726 citations · Full text

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Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

Robert F. Newbold, Robert W. Overell · Nature · 1983 · 444 citations

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Cellular senescence as a tumor-suppressor mechanism

Judith Campisi · Trends in Cell Biology · 2001 · 378 citations

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