Experimental Deafness Caused by Etachrynic Acid

Abstract

AbstractA single large intravenous dose of etachrynic acid (20–40 mg/kg body weight) causes a rapid significant diminution in the voltages of cochlear microphonic potentials in the guinea pig. No permanent functional or morphologic alterations can be demonstrated 3 weeks following a single large intravenous dose (30 mg/kg body weight) of the drug. NotesThis study was supported by grants from the Finnish National Council for Medical Sciences and from the Paulo Foundation.