Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction*

Abstract

Elderly patients are more sensitive to the sedative action of midazolam than young patients, and the sensitivity is caused by age-dependent pharmacodynamic alterations. The age-adjusted doses used are both effective (for sedative amnesia) and safe (in terms of arterial oxygen saturation, heart rate, and blood pressure.