PLZF regulates Pbx1 transcription and Pbx1–HoxC8 complex leads to androgen-independent prostate cancer proliferation

Abstract

Androgen-independent cell line DU145 cells lack PLZF gene expression, resulting in the upregulation of Pbx1 and HoxC8 expression. The Pbx1-HoxC8 heterocomplex may lead to androgen-independent growth in prostate cancer.