Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

Dean A. Kujubu, Bradley S. Fletcher, Brian Varnum et al. · Journal of Biological Chemistry · 1991 · 1.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

Wei Xie, Jeffrey G. Chipman, Donald Robertson et al. · Proceedings of the National Academy of Sciences · 1991 · 1.7K citations

Life Sciences, Biochemistry, Molecular Biology +16

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

Jane A. Mitchell, Pravit Akarasereenont, Christoph Thiemermann et al. · Proceedings of the National Academy of Sciences · 1993 · 1.7K citations

Medicine, Pharmacology, Inflammation +9

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

Jaime L. Masferrer, Ben S. Zweifel, Pamela T. Manning et al. · Proceedings of the National Academy of Sciences · 1994 · 1.3K citations

Veterinary Medicine, Immunology, Pharmacology +17