.DELTA.-Indomycinone: A New Member of Pluramycin Class of Antibiotics Isolated from Marine Streptomyces sp.

Abstract

In a continuation of our investigation for bioactive secondary metabolites from marine microorganisms1}, we have isolated a new pluramycin type metabolite 5indomycinone (2), along with the known antibiotic /?indomycinone (1)2). Both compounds were extracted from the culture broth of a Streptomyces strain (B 8300), obtained from the collection of marine actinomycetes at Alfred-Wegener-Institute for Polar and Marine Research, Bremerhaven, Germany. Pluramycin metabolites containing the 4tf-anthra[l ,2-Z>]pyran-4,7, 1 2-trione nucleus to which amino sugars typically are attached at C-8 and C-10 positions, were most commonly isolated from terrestrial Streptomyces sp. The pluramycin analogues which lack any carbohydrate substitution are the pluramycinones such as indomycinones3). The pluramycins are a group of highly structurally evolved DNA reactive agents and found to have antimicrobial and