ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

Thomas U. Mayer, Tarun M. Kapoor, Stephen J. Haggarty et al. · Science · 1999 · 1.7K citations

Molecular Biology, Small Molecule Inhibitor, Cytoskeleton +18

A structural change in the kinesin motor protein that drives motility

Sarah E. Rice, Abel W. Lin, Daniel Safer et al. · Nature · 1999 · 804 citations

Protein Function, Kinesin Motor Protein, Macromolecular Machine +7

Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5

Tarun M. Kapoor, Thomas U. Mayer, Margaret Coughlin et al. · The Journal of Cell Biology · 2000 · 723 citations · Full text

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

Lukas C. Kapitein, Erwin J.G. Peterman, Benjamin H. Kwok et al. · Nature · 2005 · 690 citations · Full text

Protein Function, Cell Division, Protein Folding +10

S-Trityl-L-cysteine Is a Reversible, Tight Binding Inhibitor of the Human Kinesin Eg5 That Specifically Blocks Mitotic Progression

Dimitrios A. Skoufias, Salvatore DeBonis, Yasmina Saoudi et al. · Journal of Biological Chemistry · 2006 · 281 citations · Full text