Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

Life Sciences, Cell Biology, Apoptosis +14

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Peng Li, Deepak Nijhawan, I. Imawati Budihardjo et al. · Cell · 1997 · 7.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

Ruth M. Kluck, Ella Bossy‐Wetzel, Douglas R. Green et al. · Science · 1997 · 4.7K citations

Life Sciences, Biochemistry, Cell Biology +17

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

F. Michael Yakes, Bennett Van Houten · Proceedings of the National Academy of Sciences · 1997 · 1.8K citations

Life Sciences, Cell Biology, Molecular Biology +15

Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt

Ju-Hyung Woo, Young Ho Kim, Yun‐Jung Choi et al. · Carcinogenesis · 2003 · 443 citations · Full text

Life Sciences, Oncology, Pharmacology +17