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Leptin Induces IL-6 Expression through OBRl Receptor Signaling Pathway in Human Synovial Fibroblasts

DOIFull Paper Access

82

Citations

42

References

2013

Year

Wei‐Hung Yang, Shan‐Chi Liu, Chun‐Hao Tsai, Yi‐Chin Fong, Shoou-Jyi Wang, Yung-Sen Chang, Chih‐Hsin Tang
PLoS ONE

Abstract

Our results showed that leptin activates the OBRl receptor, which in turn activates IRS-1, PI3K, Akt, and AP-1 pathway, leading to up-regulation of IL-6 expression.

References

YearCitations

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