HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

Genetics, Molecular Biology, Hif-1 Subunits +21

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

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Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

Fouad Shalaby, Janet Rossant, Terry P. Yamaguchi et al. · Nature · 1995 · 3.9K citations

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