Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: Synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

K M Tewey, Thomas C. Rowe, Liu Yang et al. · Science · 1984 · 1.5K citations

Medicine, Molecular Biology, Pharmacology +17

Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids

Hiroshi Koga, Akira Itoh, Satoshi Murayama et al. · Journal of Medicinal Chemistry · 1980 · 483 citations

Pharmacy, Chemistry, Medicinal Chemistry +13

Anticancer and antioxidant activity of synthetic chalcones and related compounds

Ruby John Anto, K. B. SUKUMARAN, Girija Kuttan et al. · Cancer Letters · 1995 · 324 citations

Medicine, Medicinal Chemistry, Oncology +16

Aqueous solubilities of some variously substituted quinolone antimicrobials

Danna L. Ross, Christopher M. Riley · International Journal of Pharmaceutics · 1990 · 292 citations

Pharmacy, Medicinal Chemistry, Pharmaceutical Analysis +5