Concepedia

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes

William McCoull, Matthew S. Addie, Alan M. Birch, Susan Birtles, Linda K. Buckett, Roger J. Butlin, Suzanne S. Bowker, Scott Boyd, Stephen J. Chapman, Robert D. M. Davies,

Bioorganic & Medicinal Chemistry Letters · 2012 · 44 citations · 16 references

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References

16

Multi‐way principal components‐and PLS‐analysis

Svante Wold, Paul Geladi, Kim H. Esbensen et al. · Journal of Chemometrics · 1987 · 742 citations

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DGAT2 Is a New Diacylglycerol Acyltransferase Gene Family

Kathryn Lardizabal, Nicholas Wagner, Annette Wyrick et al. · Journal of Biological Chemistry · 2001 · 368 citations · Full text

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Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases

Jingsong Cao, Yingjiang Zhou, Haibing Peng et al. · Journal of Biological Chemistry · 2011 · 154 citations · Full text

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Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

Gang Zhao, Andrew J. Souers, Martin J. Voorbach et al. · Journal of Medicinal Chemistry · 2008 · 140 citations · Full text

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Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

Robert L. Dow, Jiancheng Li, Michael P. Pence et al. · ACS Medicinal Chemistry Letters · 2011 · 104 citations · Full text

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