Concepedia

A Therapeutic Drug Monitoring Algorithm for Refining the Imatinib Trough Level Obtained at Different Sampling Times

Yanfeng Wang, Yen Lin Chia, Jerry Nedelman, Horst Schran, François‐Xavier Mahon, Mathiéu Molimard

Therapeutic Drug Monitoring · 2009 · 87 citations · 12 references

Abstract

By using the algorithm, the pharmacokinetic sampling window can be extended to a wider window to make the trough sampling easy to implement in the clinical setting, provided that the sampling time and dosing time are accurately recorded.

References

12

Five-Year Follow-up of Patients Receiving Imatinib for Chronic Myeloid Leukemia

Brian Druker, François Guilhot, Stephen G. O’Brien et al. · New England Journal of Medicine · 2006 · 3.5K citations · Full text

Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor

Michael C. Heinrich, Christopher L. Corless, George D. Demetri et al. · Journal of Clinical Oncology · 2003 · 2.3K citations

Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study

Richard A. Larson, Brian Druker, François Guilhot et al. · Blood · 2008 · 631 citations · Full text

Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia

Stéphane Picard, Karine Titier, Gabriel Étienne et al. · Blood · 2006 · 604 citations · Full text

MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models

François‐Xavier Mahon, Françis Belloc, Valérie Lagarde et al. · Blood · 2003 · 537 citations · Full text