Concepedia

The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test

Beatrice Oneda, Séverine Crettol, Evelyne Jaquenoud Sirot, Murielle Bochud, Nicolas Ansermot, Chin B. Eap

Pharmacogenetics and Genomics · 2009 · 114 citations · 52 references

DOI

Abstract

The SNP POR*28 seems to be a better genetic marker of the variability of total CYP3A activity in vivo than CYP3A4, CYP3A5 and CYP3A7 genetic variants.

References

52

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

Peter Kuehl, Jiong Zhang, Yvonne Lin et al. · Nature Genetics · 2001 · 2.2K citations

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Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects

William E. Evans, Howard L. McLeod · New England Journal of Medicine · 2003 · 1.8K citations

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Three-dimensional structure of NADPH–cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes

Ming Wang, David L. Roberts, Rosemary Paschke et al. · Proceedings of the National Academy of Sciences · 1997 · 737 citations · Full text

The genetic determinants of the CYP3A5 polymorphism

Elisabeth Hustert, Michael Haberl, Oliver Burk et al. · Pharmacogenetics · 2001 · 670 citations

Sex Is A Major Determinant of Cyp3a4 Expression in Human Liver

Renzo Wolbold, Kathrin Klein, Oliver Burk et al. · Hepatology · 2003 · 495 citations · Full text

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