Concepedia

Specific Killing of Rb Mutant Cancer Cells by Inactivating TSC2

Binghui Li, Gabriel M. Gordon, Charles H. Du, Jinhua Xu, Wei Du

Cancer Cell · 2010 · 71 citations · 30 references

DOIFull text

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Concepts

References

30

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella et al. · New England Journal of Medicine · 2004 · 11.5K citations

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<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

J. Guillermo Paez, Pasi A. Jänne, Jeffrey C. Lee et al. · Science · 2004 · 9.4K citations

, , +17

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3.1K citations

, , +6

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

Laura Harrington, Greg M. Findlay, Simon Wigfield et al. · The Journal of Cell Biology · 2004 · 1.1K citations · Full text

, , +17

ATP citrate lyase inhibition can suppress tumor cell growth

Georgia Hatzivassiliou, Fangping Zhao, Daniel E. Bauer et al. · Cancer Cell · 2005 · 1.1K citations · Full text

, , +14