Opposite Effective Connectivity in the Posterior Cingulate and Medial Prefrontal Cortex between First-Episode Schizophrenic Patients with Suicide Risk and Healthy Controls

Abstract

The hyper-connectivity from the left posterior cingulate cortex to the left medial prefrontal cortex may suggest that the abnormal effective connectivity was associated with risk for schizophrenia. The hypo-connectivity in the opposite direction may represent a possible correlate of increased vulnerability to suicide attempt.