Concepedia

Carbamylated-Oxidized LDL: Proatherosclerotic Effects on Endothelial Cells and Macrophages

Eugene O. Apostolov, Ercan Ok, Samuel A. Burns, Safia Nawaz, Alena V. Savenka, Sudhir V. Shah, Alexei G. Basnakian

Journal of Atherosclerosis and Thrombosis · 2013 · 36 citations · 23 references

DOIFull text

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Abstract

Our study demonstrated that LDL particles can be simultaneously carbamylated and oxidized and modifications are likely coexisting in the same LDL particle. We also demonstrated proatherosclerotic properties of coxLDL and proposed its role in atherosclerosis.

References

23

Protein carbamylation links inflammation, smoking, uremia and atherogenesis

Zeneng Wang, Stephen J. Nicholls, E. René Rodríguez et al. · Nature Medicine · 2007 · 699 citations

, , +3

Presence of a modified low density lipoprotein in humans.

P Avogaro, Gabriele Bittolo Bon, G. Cazzolato · Arteriosclerosis An Official Journal of the American Heart Association Inc · 1988 · 376 citations · Full text

, , +19

FOAM CELL APOPTOSIS AND THE DEVELOPMENT OF THE LIPID CORE OF HUMAN ATHEROSCLEROSIS

László Hegyi, Jeremy N. Skepper, N. Cary et al. · The Journal of Pathology · 1996 · 166 citations

, , +20

Carbamylated low-density lipoprotein induces death ofendothelial cells: A link to atherosclerosis in patients with kidney disease

Ercan Ok, Alexei G. Basnakian, Eugene O. Apostolov et al. · Kidney International · 2005 · 155 citations · Full text

, , +14

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

Wei Zhao, Merina Varghese, Shrishailam Yemul et al. · Molecular Neurodegeneration · 2011 · 131 citations · Full text