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Publication | Open Access

Protein Phosphatase 2A Mediates Dormancy of Glioblastoma Multiforme-Derived Tumor Stem-Like Cells during Hypoxia

DOIFull Paper Access

65

Citations

53

References

2012

Year

Christoph P. Hofstetter, Jan-Karl Burkhardt, Benjamin J. Shin, Demirkan Gursel, Lynn Mubita, Ramana Gorrepati, Cameron Brennan, Eric C. Holland, John A. Boockvar
PLoS ONE

Abstract

Our results suggest that PP2A activity predicts poor survival in GBM. PP2A appears to reduce the metabolic demand of hypoxic TSCs and enhances tumor cell survival. Modulation of PP2A may be a potential target for cancer therapy.

References

YearCitations

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