A GAL4-based yeast three-hybrid system for the identification of small molecule–target protein interactions

A novel genetic system to detect protein–protein interactions

Stanley Fields, Ok-kyu Song · Nature · 1989 · 6.1K citations

Interactomics, Natural Sciences, Protein Analysis +7

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

J. Wade Harper · Cell · 1993 · 5.6K citations

Molecular Pharmacology, G1 Cyclin-dependent Kinases, Signal Transduction +10

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

Inflammation, Cytokine, Signal Transduction +13

Improved method for high efficiency transformation of intact yeast cells

Daniel Gietz, Andrew St. Jean, Robin A. Woods et al. · Nucleic Acids Research · 1992 · 3.3K citations · Full text

Engineering, Medicine, Biotechnology +7

A general method of<i>in vitro</i>preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

Russell Higuchi, Barbara Krummel, Randall K. Saiki · Nucleic Acids Research · 1988 · 2.4K citations · Full text