Concepedia

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

Shída Yousefi, Remo Perozzo, Inès Schmid, Andrew Ziemiecki, Thomas Schaffner, Léonardo Scapozza, Thomas Brunner, Hans‐Uwe Simon

Nature Cell Biology · 2006 · 1.3K citations · 30 references

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30

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

Séamus J. Martin, Chris Reutelingsperger, Anne J. McGahon et al. · The Journal of Experimental Medicine · 1995 · 2.9K citations · Full text

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Xueping Qu, Jie Yu, Govind Bhagat et al. · Journal of Clinical Investigation · 2003 · 2.2K citations · Full text

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Zhenyu Yue, Chingwen Yang, Arnold J. Levine et al. · Proceedings of the National Academy of Sciences · 2003 · 2.1K citations · Full text

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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

Jerry E. Chipuk, Tomomi Kuwana, Lisa Bouchier‐Hayes et al. · Science · 2004 · 2K citations

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p53 Has a Direct Apoptogenic Role at the Mitochondria

Motohiro Mihara, Susan Erster, Alexander Zaika et al. · Molecular Cell · 2003 · 1.8K citations · Full text

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