Isolation and characterization of DNA topoisomerase II from cauliflower inflorescences

Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases

Lewis M. Siegel, Kenneth J. Monty · Biochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis · 1966 · 2.2K citations

Life Sciences, Biochemistry, Molecular Biology +10

Mechanism of action of nalidixic acid: Purification of <i>Escherichia coli nalA</i> gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

Akio Sugino, Craig L. Peebles, Kenneth N. Kreuzer et al. · Proceedings of the National Academy of Sciences · 1977 · 782 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

Stephen DiNardo, K Voelkel, Rolf Sternglanz · Proceedings of the National Academy of Sciences · 1984 · 685 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

Eric M. Nelson, K M Tewey, Leroy F. Liu · Proceedings of the National Academy of Sciences · 1984 · 562 citations

Medicine, Molecular Biology, Pharmacology +15

Type II DNA topoisomerases: Enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break

Leroy F. Liu, Chen Liu, Bruce Alberts · Cell · 1980 · 546 citations

Life Sciences, Biochemistry, Molecular Biology +14