Functional analysis in serum from atypical Hemolytic Uremic Syndrome patients reveals impaired protection of host cells associated with mutations in factor H

Genetic studies into inherited and sporadic hemolytic uremic syndrome

Paul Warwicker, Timothy H.J. Goodship, Rosemary L. Donne et al. · Kidney International · 1998 · 493 citations

Life Sciences, Genetics, Molecular Genetics +12

Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway

Douglas T. Fearon · Proceedings of the National Academy of Sciences · 1978 · 416 citations · Full text

Life Sciences, Biochemistry, Immunology +12

Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H.

Seppo Meri, Michael K. Pangburn · Proceedings of the National Academy of Sciences · 1990 · 414 citations

Life Sciences, Biochemistry, Immunology +11

Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome

Tamara Manuelian, Jens Hellwage, Seppo Meri et al. · Journal of Clinical Investigation · 2003 · 342 citations · Full text

Medicine, Genetics, Molecular Genetics +15

Factor H Mutations in Hemolytic Uremic Syndrome Cluster in Exons 18–20, a Domain Important for Host Cell Recognition

Anna Richards, M. Buddles, Rosemary L. Donne et al. · The American Journal of Human Genetics · 2001 · 311 citations · Full text

Medicine, Genetics, Molecular Genetics +15