Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation

Survival of acute myeloid leukemia cells requires PI3 kinase activation

Qing Xu, Serge-Emile Simpson, Timothy J. Scialla et al. · Blood · 2003 · 471 citations · Full text

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

Hitoshi Kiyoi, Masayuki Towatari, Shohei Yokota et al. · Leukemia · 1998 · 446 citations

Flt3 Gene, Developmental Biology, Genetic Disorder +8

Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase

Yasuo Kubota · The EMBO Journal · 2001 · 59 citations · Full text

Signal Transduction, Signaling Pathway, Receptor Tyrosine Kinase +6

CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses.

Hiroshi Ohnishi, J A Ledbetter, Steven B. Kanner et al. · The Journal of Immunology · 1995 · 33 citations · Full text

The role of phosphatidylinositol 3'-kinase and its downstream signals in erbB-2-mediated transformation.

Kathleen M. Woods Ignatoski, Donna L. Livant, Sonja M. Markwart et al. · PubMed · 2003 · 31 citations

Molecular Biology, Cancer Biology, Tumor Biology +19