A General Method for Convergent Synthesis of Polycyclic Ethers Based on Suzuki Cross-Coupling: Concise Synthesis of the ABCD Ring System of Ciguatoxin

Abstract

A general method for convergent assembly of polyether structure has been developed based on palladium(0)-mediated Suzuki cross-coupling reaction of alkylboranes with cyclic ketene acetal phosphates. The present method allowed for coupling of medium-sized ether rings and thus a concise synthesis of the ABCD ring system of ciguatoxins has been achieved.