Homozygous factor V Leiden and double heterozygosity for factor V Leiden and prothrombin mutation

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

Björn Dahlbäck, Martin Carlsson, Peter J. Svensson · Proceedings of the National Academy of Sciences · 1993 · 2K citations

Medicine, Hematology, Clinical Biochemistry +15

World distribution of factor V Leiden

David C. Rees, Michael J. Cox, J. B. Clegg · The Lancet · 1995 · 1.2K citations

Medicine, Genetics, Genetic Epidemiology +10

Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation

Jan P. Vandenbroucke, Ted Koster, Frits R. Rosendaal et al. · The Lancet · 1994 · 1.1K citations

Medicine, Hematology, Obstetrics +17

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance) [see comments]

FR Rosendaal, Ted Koster, PH Reitsma · Blood · 1995 · 1K citations

Medicine, Genetics, Hematology +16

The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients

Paolo Prandoni, Franco Noventa, Angelo Ghirarduzzi et al. · Haematologica · 2007 · 770 citations · Full text

Medicine, Hematology, Pharmacotherapy +17