International Immunology · 1993 · 22 citations · 0 references
Life SciencesImmunologyMolecular BiologyCellular ImmunologyImmunology Of Infectious DiseasesMonoclonal AntibodiesAntibody CharacterizationAntibody-antigen RecognitionAntigen PresentationAntigen RecognitionMajor Histocompatibility ComplexT Cell ActivationClass I Histocompatibility AntigensMhc Antigen PresentationMhc Class I MoleculesPeptide Antigen PresentationPeptide EpitopesSynthetic Peptide AntigensT Cell Epitope RecognitionT-cell Epitopes
Monoclonal antibodies which recognize a synthetic peptide derived from influenza virus nucleoprotein in association with a murine class I MHC molecule (Kd) have been isolated. One such antibody has been characterized and shown to react neither with the peptide nor with the Kd molecule, but only with the Kd-peptide complex. Evidence is given that it recognizes the naturally processed peptide located in the peptide binding groove, i.e. the antigenic moiety presented to T cells.