Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Otmane Boussif, Frank Lezoualc’h, Maria Antonietta Zanta et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Pharmacy, Biotechnology, Pharmaceutics +17

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

Life Sciences, Cell Biology, Molecular Biology +13

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

Cell · 1993 · 2.5K citations · Full text

Life Sciences, Genetics, Molecular Biology +10

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

Reiner U. Jänicke, Michael L. Sprengart, Mas Rina Wati et al. · Journal of Biological Chemistry · 1998 · 2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

Keisuke Kuida, Timothy S. Zheng, Songqing Na et al. · Nature · 1996 · 1.9K citations

Life Sciences, Neurobiology, Neuroscience +14