3‐Hydroxy‐3‐Methylglutaryl‐CoA‐Like Synthases Direct the Formation of Methyl and Ethyl Side Groups in the Biosynthesis of the Antibiotic Myxovirescin A

Abstract

Deletion of taF, a homologue of 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS), causes a switch in the myxovirescin programming algorithm and leads to the production of a novel myxovirescin analogue with a shorter side chain. These results provide the first in vivo evidence for the role of HMGS-like enzymes in the incorporation of both acetate- and propionate-derived units into polyketide scaffolds. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2007/z700017_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.