Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration

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Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science · 2003 · 4.1K citations

Life Sciences, Biochemistry, Neuroscience +17

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

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Life Sciences, Genetics, Molecular Genetics +17

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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Life Sciences, Neurobiology, Neuroscience +15

Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

Frédéric Saudou, Steven Finkbeiner, Didier Devys et al. · Cell · 1998 · 1.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light

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Natural Sciences, Biochemistry, Molecular Biology +12