Concepedia

Proteostasis Breakdown

Proteostasis Breakdown is a pathological process in neurodegeneration biophysics characterized by the failure of cellular mechanisms responsible for maintaining protein homeostasis, leading to the accumulation of misfolded or aggregated proteins.

42

Publications

2.4K

Citations

297

Authors

141

Institutions

Publications per year

2017–2026

31

Parents

Publications

42

Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis

Eric J. Solís, Jai Prakash Pandey, Xu Zheng et al. · Molecular Cell · 2016 · 191 citations · Full text

, , +16

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration

Andrey S. Tsvetkov, Montserrat Arrasate, Sami J. Barmada et al. · Nature Chemical Biology · 2013 · 180 citations · Full text

, , +14

An Intracellular Pathogen Response Pathway Promotes Proteostasis in C. elegans

Kirthi C. Reddy, Tal Dror, Jessica N. Sowa et al. · Current Biology · 2017 · 144 citations

, , +13

Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy

Tania Zaglia, Giulia Milan, Aaron Ruhs et al. · Journal of Clinical Investigation · 2014 · 143 citations · Full text

, , +17

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain

Fabio Di Domenico, Raffaella Coccia, Annalisa Cocciolo et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2013 · 138 citations

, , +17

1–5 of 42

Authors

297

  1. SS
    Shaarika Sarasija

    Albany Medical Center Hospital, United States

    2 publications · 57 citations

    2

    h-index

  2. BL
    Bingwei Lu

    Stanford University, United States

    2 publications · 175 citations

    2

    h-index

  3. JT
    Jocelyn T. Laboy

    Albany Medical Center Hospital, United States

    2 publications · 57 citations

    2

    h-index

  4. ZA
    Zahra Ashkavand

    Albany Medical Center Hospital, United States

    2 publications · 57 citations

    2

    h-index

  5. KR
    Kenneth R. Norman

    Albany Medical Center Hospital, United States

    2 publications · 57 citations

    2

    h-index

1–5 of 297

Institutions

141

  1. Harvard University

    Cambridge, United States

    4 h-index

    9 publications

    1K citations

  2. University of Florida

    Gainesville, United States

    3 h-index

    18 publications

    856 citations

  3. Max Planck Society

    Munich, Germany

    2 h-index

    4 publications

    386 citations

  4. Washington University in St. Louis

    St Louis, United States

    2 h-index

    6 publications

    696 citations

  5. University of Coimbra

    Coimbra, Portugal

    2 h-index

    7 publications

    313 citations

  6. University of California, San Francisco

    San Francisco, United States

    2 h-index

    5 publications

    436 citations

  7. Albany Medical Center Hospital

    Albany, United States

    2 h-index

    11 publications

    311 citations

  8. Johns Hopkins University

    Baltimore, United States

    2 h-index

    7 publications

    405 citations

1–8 of 141

Venues

  1. Current Biology

    2 publications · 264 citations

    2

    h-index

  2. Molecular Cell

    2 publications · 302 citations

    2

    h-index

  3. Aging Cell

    2 publications · 57 citations

    2

    h-index

  4. Nature Communications

    2 publications · 96 citations

    2

    h-index

  5. International Journal of Molecular Sciences

    IJMS · 2 publications · 36 citations

    2

    h-index

1–5