Macrophages synthesise and release prostaglandins in response to inflammatory stimuli

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Thrombopoiesis, Thrombosis, Biochemistry +12

Lysosomes in biology and pathology

Food and Cosmetics Toxicology · 1977 · 2K citations

Cell Pathology, Lysosomal Storage Disease, Natural Sciences +10

The importance of phospholipase-A2 in prostaglandin biosynthesis

Roderick J. Flower, Geoffrey J. Blackwell · Biochemical Pharmacology · 1976 · 647 citations

Biosynthesis, Biochemistry, Natural Sciences +4

A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro.

S. Joseph Leibovich, Russell Ross · PubMed · 1976 · 581 citations · Full text

Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

S L Hong, Lawrence Levine · Proceedings of the National Academy of Sciences · 1976 · 571 citations · Full text

Inflammation, Anti-inflammatory, Molecular Physiology +13