Nicotinic receptor binding of [3H]cytisine, [3H]nicotine and [3H]methylcarbamylcholine in rat brain

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

The Binding of Agonists to Brain Muscarinic Receptors

N.J.M. Birdsall, A. S. V. Burgen, Edward C. Hulme · Molecular Pharmacology · 1978 · 676 citations

Medicine, Neurobiology, Pharmacology +17

Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions

S.J. Enna, Solomon H. Snyder · Brain Research · 1975 · 634 citations

Life Sciences, Neurobiology, Neuroscience +14

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

A. De Léan, Arthur A. Hancock, Robert J. Lefkowitz · Molecular Pharmacology · 1982 · 594 citations

Medicine, Pharmacology, Molecular Pharmacology +14

Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors

CW Luetje, James W. Patrick · Journal of Neuroscience · 1991 · 560 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17